Most molecules bind. 94% never cross the blood-brain-barrier. We find the ones that do — in days, not decades.
Molecules don't fail because they don't bind. They fail because they never arrive. We engineered around delivery — not around docking.
A mouse hit isn't a human hit. We simulate across 10 species so the surprises happen on a server — not in a Phase I.
Parallel discovery for canine cognitive dysfunction, epilepsy and anxiety — a faster regulatory path that generates dual-species validation data alongside the human pipeline.
A closed-loop translational intelligence platform. 10,000+ CNS targets across 791 indications and 10 species models. From concept to clinic, every decision is computed, validated and ranked.
Six engines, sixty-five gates, one ruthless principle: every candidate gets one chance to disqualify itself before it advances. Fail at gate twelve — not at clinical month thirty-six.
Most pipelines spend their compute on docking — the gate that arrives in month thirty-six. NPE inverts the order: causality, BBB transport and ADMET come before any physics-heavy run, so the 90+% of molecules that were never going to make it are dropped on day one.
Built in Switzerland. Engineered around one conviction: the Blood-Brain Barrier is a solvable computational problem — and CNS doesn't have to mean a 94% failure rate.
Most CNS molecules don't fail because they don't bind. They fail because they never reach the brain. The Blood-Brain Barrier is where billion-dollar programs go to die — usually in Phase II, after the chemistry already worked. The industry treats delivery as a late-stage surprise; we treat it as gate one.
NeuroPrecision-Engine is the discovery stack engineered around the blood brain barrier from the first line of code. Real physics, real biology, CNS-trained machine learning, quantum-enhanced scoring where classical methods lose resolution. No LLM wrappers. Real numbers, every gate.
A science-and-technology founding pair. One Chief Scientist, one Chief Technologist — sharing one conviction: the blood brain barrier is solvable, and CNS deserves a discovery stack engineered for it from the first line of code.
Designs the 65-gate pipeline from first principles. Owns target selection, BBB biology, validation strategy and pharma relationships.
Translates the pipeline into a live, GPU-accelerated system. Owns infrastructure, frontend, deployment, integrations and 24/7 operations.
Co-founder and platform architect. Designed the 65-gate pipeline from first principles and leads the science: target selection, BBB biology, validation strategy and pharma relationships.
Co-founder and technology lead. Translated the pipeline into a live, GPU-accelerated system and runs the engineering: infrastructure, frontend, deployment, integrations and 24/7 operations.
Most CNS failures are failures of delivery, not of chemistry. We moved that question to the beginning of the pipeline — modelled through physics, biology, machine learning and quantum-enhanced scoring, gate by gate. Built in Sursee, Switzerland.
Pharma. Biotech. Academia. CROs. Bring us a target, a disease, or a question — we'll show you the answer in days, not quarters.
Tell us the indication or target class — we'll get back to you within 48 hours.
All 791 indications carry human ICD-10 codes — that's the regulatory anchor. Each indication is also tagged with the 10 species commonly used to model it preclinically (mouse, rat, dog, pig, macaque, marmoset, zebrafish, fly, C. elegans, human). Filter by category, species or just type to search.
Pick one of 791 indications. The Engine harvests the targets, builds the compound library, and runs all 65 gates against that disease's biology — automatically.
Type a name or ICD-10 — Glioblastoma, Alzheimer's, Rett syndrome, anything in the catalog.
Open Targets ≥0.4 association + STRING-PPI hop-2 + UniProt cross-refs build the target list — no manual seed needed.
ChEMBL bioactivity (pchembl ≥4.0) for the top targets, plus PubChem CNS focus set, plus DrugBank ATC N0x — deduplicated by InChIKey.
BBB filter first, then ADMET, then docking, then quantum scoring — fail-fast at every step. Final dossier in days, not quarters.
Already know the protein? Type its symbol or UniProt ID. The Engine harvests every known ligand, generates new ones, and runs all 65 gates around that single target.
Symbol (EGFR, SNCA, GBA1, LRRK2, MAPT, BACE1…) or UniProt accession — anything druggable.
UniProt → AlphaFold v6 + every PDB drug-bound template the target has. Class-aware: kinase, GPCR, ion-channel each handled differently.
Pull every known active from PubChem and ChEMBL, expand chemical space with structure-aware generation, and dedup.
Same gate sequence as a disease run — but every result is anchored to your one target. Top-10 lead dossier ranked by ΔG, BBB, safety, and novelty.
A drug that works in a mouse fails in humans 89% of the time. We close that gap by simulating across the entire evolutionary tree — and combining the signals into a single human-translation score.
PBPK with species-specific brain compartments + transporter expression (P-gp, BCRP, MRP1) gives a brain-Cmax for each animal.
Sequence + structural conservation of the target between species; weight is downgraded where active-site residues diverge.
Reactome + KEGG cross-species pathway maps flag where compensatory biology breaks the model.
Each species' signal becomes a posterior. We fuse them into a single Translation Reliability Score with a calibrated confidence interval — that's the number that goes in the dossier.
NeuroPrecision-Engine is a pre-incorporation venture (no GmbH, no AG, no commercial-register entry). The two natural persons jointly responsible (gemeinsam verantwortlich) for data processing on this Website within the meaning of Art. 5 lit. j of the Swiss Federal Act on Data Protection (nFADP, SR 235.1) and, where applicable, Art. 26 GDPR are: Suvija Münow-Suthakaran and Tahnee Jessica Münow, Sursee, Canton Lucerne, Switzerland. Privacy enquiries: info@neuroprecision-engine.com.
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We may update this policy from time to time. The current version applicable to your visit is always the version published on this page on the date of that visit.
Version 1.0 — Last updated: February 2026, Sursee, Switzerland.
NeuroPrecision-Engine is a pre-incorporation venture. It is not yet registered as a legal entity (no GmbH, no AG, no entry in the Swiss Commercial Register). The Website and its content are operated personally and jointly by the two founders below as natural persons, in the form of a simple partnership pursuant to Art. 530 et seq. of the Swiss Code of Obligations (CO / OR, SR 220):
General contact: info@neuroprecision-engine.com · Partnership / pharma enquiries: Contact@neuroprecision-engine.com
Sursee, Canton Lucerne, Switzerland
Content on this website is provided in good faith for informational purposes and does not constitute a medical, scientific, regulatory or investment recommendation. No warranty is given regarding accuracy, completeness or timeliness. The operators exclude liability to the maximum extent permitted by Art. 100 and Art. 101 CO. External links lead to third-party websites over which the operators have no influence and accept no responsibility.
All content, design elements, text, images, source code, the NPE wordmark, the 65-gate pipeline architecture and the 791-disease catalogue on this website are the intellectual property of the operators or used with permission of the rights holders. Reproduction, modification, public display or commercial use, in whole or in part, without prior written consent is not permitted (Art. 9 ff. URG, SR 231.1; Art. 28 / 29 ZGB; Art. 1 MSchG, SR 232.11).
This Website and its use are governed exclusively by Swiss substantive law (CO / OR, SR 220; ZGB, SR 210; nFADP, SR 235.1; URG, SR 231.1; MSchG, SR 232.11). Sole place of jurisdiction is the competent court in Sursee, Canton Lucerne, Switzerland (Art. 32 ZPO, SR 272), subject to mandatory consumer-protection forums under the visitor's domicile law where applicable. The full Terms apply — see our AGB.
These General Terms and Conditions ("AGB") govern the access to and use of the website neuroprecision-engine.com (the "Website") and any non-binding pre-incorporation communication with the operators. They are based on Swiss law, in particular the Swiss Code of Obligations (CO / OR, SR 220) and the Swiss Civil Code (ZGB, SR 210).
The Website is operated jointly and personally by Suvija Münow-Suthakaran and Tahnee Jessica Münow as natural persons in Sursee, Canton Lucerne, Switzerland. NeuroPrecision-Engine is a pre-incorporation venture and is not yet registered as a legal entity (Art. 530 et seq. CO concerning a simple partnership applies between the two natural persons; no commercial register entry exists). All contractual statements and any future binding offers therefore originate from the two natural persons themselves and not from a corporate body.
These AGB apply to every visitor and user of the Website. By accessing the Website you accept these terms in the version available at the time of your visit. The operators may amend these AGB at any time; the version applicable to a given visit is the version published on this page on the date of that visit.
All content on the Website (including, without limitation, descriptions of the 65-gate pipeline, statistical figures, disease catalogue, in-silico results, illustrations and screenshots) is provided for general information and demonstration purposes only. It is not a medical, scientific, regulatory, legal, financial or investment recommendation, and it does not replace independent professional advice. The Website does not constitute a binding offer (Art. 7 CO).
The operators take reasonable care in compiling and presenting the information on the Website, but make no warranty as to its accuracy, completeness, timeliness, fitness for a particular purpose, or non-infringement of third-party rights. In particular, computational results displayed on this Website are illustrative; running the actual pipeline on a given target or indication is required to obtain a binding scientific result.
To the fullest extent permitted by mandatory Swiss law (Art. 100 and Art. 101 CO), the operators exclude any liability for direct, indirect, incidental or consequential damages arising from access to or use of the Website, from reliance on its content, or from temporary unavailability or technical failure of the Website. Liability for unlawful intent or gross negligence remains reserved as required by Art. 100(1) CO.
The Website may contain links to third-party websites (e.g. UniProt, ChEMBL, ClinicalTrials.gov, AlphaFold-DB, NVIDIA NIM endpoints). The operators have no influence on the content, availability or data-protection practices of those third parties and accept no liability for their content. Following such links is at the visitor's own responsibility.
All content on the Website — including text, design elements, the NPE logo, source code, illustrations, screenshots, the 65-gate pipeline architecture and the 791-disease catalogue — is the intellectual property of the operators or used with permission of the respective rights holders. Reproduction, distribution, public display, modification, reverse engineering or commercial use, in whole or in part, requires the prior written consent of the operators (Art. 9 ff. of the Swiss Copyright Act, URG, SR 231.1; Arts. 28 and 29 ZGB regarding personality rights).
"NeuroPrecision-Engine", "NPE" and the NPE wordmark are used by the operators as commercial designations within the meaning of Art. 1 of the Swiss Trademark Act (MSchG, SR 232.11). Use by third parties without prior written consent is not permitted.
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The processing of personal data on this Website is governed by our Privacy Policy and complies with the Swiss Federal Act on Data Protection (FADP / nFADP, SR 235.1) and, where applicable, the EU General Data Protection Regulation (GDPR, Reg. (EU) 2016/679). See the Privacy Policy for details.
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These AGB and any non-contractual obligations arising from or in connection with the Website are governed exclusively by Swiss substantive law, with the express exclusion of conflict-of-laws rules and the United Nations Convention on Contracts for the International Sale of Goods (CISG). Sole place of jurisdiction is the competent court in Sursee, Canton Lucerne, Switzerland — subject to any mandatory consumer-protection forum a visitor may have under their Swiss or EU domicile law (Art. 32 of the Swiss Code of Civil Procedure, ZPO, SR 272; Art. 114 PILA, SR 291).
Version 1.0 — published February 2026, Sursee, Switzerland.